Publications
Now showing items 1-40 of 1372
Antimicrobial compounds from natural sources
(2014)
The nature is a generous source of a number of compounds with potential application for the treatment of several diseases including the infectious diseases, which is of utmost concern for the modern medicine due to the ...
Antimicrobial peptides and Complement - Maximising the inflammatory response
(2015)
Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, ...
Antimicrobial Resistance and Virulence Common Mechanisms
(2017)
Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously ...
Advances in Seed Biology
(2015)
The seed plays a fundamental role in plant reproduction as well as a key source of energy, nutrients and raw materials for developing and sustaining humanity. With an expanding and generally more affluent world population ...
Arm and Hand Movement: Current Knowledge and Future Perspective
(2015)
This Research Topic is devoted to arm and hand movement in health as well as in several disease conditions. It is a collection of several original research papers and reviews, clinical case studies, hypothesis and theory ...
ATP-gated P2X receptors in Health and Disease
(2015)
Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial ...
Bifidobacteria and Their Role in the Human Gut Microbiota
(2017)
The human intestine is home of an almost inconceivable large number of microorganisms. The human gut microbiota can therefore be pictured as an organ placed within a host organism. The human gut microbiome, which in total ...
Ca2+ Signaling and Heart Rhythm
(2016)
Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy ...
Ca2+ and Ca2+-interlocked Membrane Guanylate Cyclase Modulation
(2015)
The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but ...
CaMKII in Cardiac Health and Disease
(2014)
The calcium-calmodulin dependent protein kinases (CaMKs) are a broadly expressed family of calcium-sensitive intracellular kinases, which are responsible for transducing cytosolic calcium signals into phosphorylation-based ...
CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom
(2015)
CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and ...
The changing faces of glutathione, a cellular protagonist
(2015)
Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype ...
Antibiotic Resistance in Aquatic Systems
(2017)
Rivers, lakes and the ocean receive antibiotic resistance genes from human environments. The aquatic environments are a huge reservoir and exchange stage of antibiotic resistance genes.
Audiovisual Speech Recognition: Correspondence between Brain and Behavior
(2014)
Perceptual processes mediating recognition, including the recognition of objects and spoken words, is inherently multisensory. This is true in spite of the fact that sensory inputs are segregated in early stages of ...
Advances in Microalgae Biology and Sustainable Applications
(2016)
It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are ...
Advances in Modern Mental Chronometry
(2015)
Mental chronometry encompasses all aspects of time processing in the nervous system and constitutes a standard tool in many disciplines including theoretical and experimental psychology and human neuroscience. Mental ...
Advances in Mechanisms of Renal Fibrosis
(2018)
Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming ...
Beyond the body? The Future of Embodied Cognition
(2016)
Embodied cognition represents one of most important research programs in contemporary cognitive science. Although there is a diversity of opinion concerning the nature of embodiment, the core idea is that cognitive processes ...
Beyond Reward: Insights from Love and Addiction
(2017)
It is an interesting topic to discuss addiction and love in the context of reward. In this e-book, we begin with an animal study of comparison between drug and natural reward. Then, some papers aim to understand the reward ...
Charged Particles in Oncology
(2018)
High-energy charged particles represent a cutting-edge technique in radiation oncology. Protons and carbon ions are used in several centers all over the world for the treatment of different solid tumors. Typical indications ...
Anaerobic Digestion
(2018)
Anaerobic digestion (AD) is a naturally-occurring biological process in soils, sediments, ruminants, and several other anoxic environments, that cycles carbon and other nutrients, and converts organic matter into a ...
Autism: The Movement Perspective
(2015)
Autism Spectrum Disorders (ASD) is portrayed as cognitive and social disorders. Undoubtedly, impairments in communication and restricted-repetitive behaviors that now define the disorders have a profound impact on social ...
Autism Spectrum Disorders: From genotypes to phenotypes
(2015)
This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests ...
Autism Spectrum Disorders (ASD) - Searching for the Biological Basis for Behavioral Symptoms and New Therapeutic Targets
(2017)
Autism Spectrum Disorder (ASD) is currently diagnosed based on a series of behavioral tests. The challenge for researchers is to try to uncover the biological basis for these typical behaviors in order to improve diagnosis ...
Autism Spectrum Disorders: Developmental Trajectories, Neurobiological Basis, Treatment Update
(2017)
This Research Topic has the aim to fill the gap of the many unresolved scientific issues on Autism Spectrum Disorders (ASD) that are still in need of investigation, Targeted treatments based on the understanding of the ...
Assessing Prenatal and Neonatal Gonadal Steroid Exposure for Studies of Human Development: Methodological and Theoretical Challenges
(2015)
There is extensive evidence from animal models that gonadal steroids, produced in fetal and neonatal life, act on the developing organism to produce sex differences far beyond the reproductive system. That early gonadal ...
Assembly of the Photosystem II Membrane-Protein Complex of Oxygenic Photosynthesis
(2017)
Photosystem II is a 700-kDa membrane-protein super-complex responsible for the light-driven splitting of water in oxygenic photosynthesis. The photosystem is comprised of two 350-kDa complexes each made of 20 different ...
Bilateral Vestibulopathy - Current Knowledge and Future Directions to Improve its Diagnosis and Treatment
(2018)
Many patients with bilateral vestibulopathy experience chronic oscillopsia due to failure of the vestibulo-ocular reflex and gait instability due to failure of vestibulo-spinal reflexes. There are numerous potential ...
Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria
(2016)
The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, ...
Bacterial Exotoxins: How bacteria fight the immune system
(2016)
The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special ...
Cancer-associated defects in the DNA damage response: drivers for malignant transformation and potential therapeutic targets
(2016)
For this eBook, and the associated Research Topic in Frontiers in Genetics, entitled: ‘Cancer-associated defects in the DNA damage response: drivers for malignant transformation and potential therapeutic targets’ we have ...
Challenging the Functional Connectivity Disruption in Neurodegenerative Diseases: New Therapeutic Perspectives through Non-Invasive Neuromodulation and Cutting-Edge Technologies
(2018)
The neurorehabilitation field is increasingly focused on understanding how to efficiently revert the effects that acute (i.e., stroke or traumatic brain injury) or chronic (i.e., neurodegenerative diseases) insults play ...
Challenges to Mean-Based Analysis in Psychology: The Contrast Between Individual People and General Science
(2016)
In a recent paper we (Speelman & McGann, 2013) argued that psychology’s reliance on data analysis methods that are based on group averages has resulted in a science of group phenomena that may be misleading about the nature ...
Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?
(2018)
Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone ...
Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases?
(2018)
Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, ...
At the doors of lexical access: The importance of the first 250 milliseconds in reading
(2014)
Correct word identification and processing is a prerequisite for accurate reading, and decades of psycholinguistic and neuroscientific research have shown that the magical moments of visual word recognition are short-lived ...
At Risk for Neuropsychiatric Disorders: An Affective Neuroscience Approach to Understanding the Spectrum
(2016)
Neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, anxiety disorders, and other mental disorders constitute about 13% of the global burden of disease surpassing both cardiovascular disease and ...
At the Crossroads: Lessons and Challenges in Computational Social Science
(2016)
The interest of physicists in economic and social questions is not new: for over four decades, we have witnessed the emergence of what is called nowadays “sociophysics” and “econophysics”, vigorous and challenging areas ...
At The Top of the Interneuronal Pyramid - Calretinin Expressing Cortical Interneurons
(2016)
It is in general well appreciated that the cortical interneurons play various important roles in cortical neuronal networks both in normal and pathological states. Based on connectivity pattern, developmental, morphological ...
Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis
(2015)
Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons ...