Publications
Now showing items 1011-1020 of 1372
Reassessing Twenty Years of Vaccine Development Against Tuberculosis
(2018)
Tuberculosis (TB) remains the prime bacterial infection worldwide with 10.4 million infections and a death toll of 1.7 million people in 2016 according to WHO statistics. Tuberculosis is caused by members of the Mycobacterium ...
Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation
(2015)
Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, ...
Prenatal Beginnings for Better Health
(2018)
Pregnancy has significant short- and long-term health impacts for mother and child, which may lead to pediatric- and adult-onset diseases. Understanding these gestational origins of disease and currently existing platforms ...
Quantum Mechanical/Molecular Mechanical Approaches for the Investigation of Chemical Systems - Recent Developments and Advanced Applications
(2018)
The QM/MM method, short for quantum mechanical/molecular mechanical, is a highly versatile approach for the study of chemical phenomena, combining the accuracy of quantum chemistry to describe the region of interest with ...
Progenitor diversity and neural cell specification in the central nervous system
(2015)
The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly ...
Proteomics of Microbial Human Pathogens
(2017)
According to the World Health Organization (WHO), in 2012 infectious diseases and related conditions account for more than 70% of premature deaths across 22 African countries and estimated 450 000 people worldwide developed ...
Protein Solubility and Aggregation in Bacteria
(2016)
Proteins suffer many conformational changes and interactions through their life, from their synthesis at ribosomes to their controlled degradation. Only folded and soluble proteins are functional. Thus, protein folding and ...
Protein Phosphorylation in Health and Disease
(2016)
Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, localization and stability ...
The Proteins of Plastid Nucleoids - Structure, Function and Regulation
(2016)
Plastids are plant cell-specific organelles of endosymbiotic origin that contain their own genome, the so-called plastome. Its proper expression is essential for faithful chloroplast biogenesis during seedling development ...
Protein Quality Controlling Systems in Plant Responses to Environmental Stresses
(2018)
Environmental stress factors negatively affect plant growth by inducing proteins dysfunction. As coping strategies, plant have developed a comprehensive protein quality controlling system (PQCS) to keep proteins homeostasis. ...