Publications
Now showing items 1261-1270 of 1372
Towards translating research to clinical practice: Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury
(2015)
Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in ...
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs
(2017)
Tens of thousands of chemicals are released into the environment every day. High-throughput screening (HTS) has offered a more efficient and cost-effective alternative to traditional toxicity tests that can profile these ...
Toxicity of Pesticides on Health and Environment
(2018)
Public policy is regularly shaken by health crises or unexpected discoveries; future directions in toxicology assessment are therefore urgently needed. Convergent evidences suggest endocrine or nervous disrupting effects ...
Transcriptional Regulation in Cancers and Metabolic Diseases
(2015)
The transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression ...
Transcellular Cycles Underlying Neurotransmission
(2015)
Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important ...
The Transcriptional Regulation of Memory
(2016)
The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, ...
Transfer Cells
(2015)
Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth ...
Transitions Between Consciousness and Unconsciousness
(2018)
Over the last years, a large body of experimental data have been generated in the attempt to understand consciousness and its neural underpinnings. In this respect, particular interest has been paid to the attempt to ...
Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations
(2017)
Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s ...
Trauma; Psychosis and Posttraumatic Stress Disorder
(2017)
There is abundant evidence showing a strong association between trauma exposure, psychotic symptoms, and posttraumatic stress disorder (PTSD). Early trauma exposure contributes to the formation of psychotic symptoms and ...