Publications
Now showing items 681-685 of 1372
Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases
(2015)
Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, ...
The molecular pathology of cognitive decline: Focus on metals
(2016)
In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing ...
Molecular Organization of Membranes: Where Biology Meets Biophysics
(2018)
Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed ...
Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications
(2015)
In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour ...
Molecular mechanisms for reprogramming hippocampal development and function by early-life stress
(2016)
The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive ...