Publications
Now showing items 41-80 of 1372
Cellular Mechanisms of Ototoxicity
(2018)
The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal ...
Cellular and Phenotypic Plasticity in Cancer
(2015)
The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various ...
Advances in Genomics and Epigenomics of Social Insects
(2017)
Social insects are among the most successful and ecologically important animals on earth. The lifestyle of these insects has fascinated humans since prehistoric times. These species evolved a caste of workers that in most ...
Animal allergens: Common protein characteristics featuring their allergenicity
(2015)
Among the many molecules present in our environment, some have the property to induce allergic sensitization and IgE-mediated reactions. The analysis of known major animal allergens has shown that most belong to single ...
Animal model studies on viral infections
(2015)
Understanding viral replication and pathogenicity properties in infected individuals is a major mission of animal virology. Animal models are essential to analyze the in vivo viral characteristics and to develop countermeasures ...
Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation
(2017)
The first real major breakthrough that laid the basis of HLA antibody detection in the field of solid organ transplantation, came with the introduction of the complement dependent cytotoxicity (CDC) test in 1964 by Terasaki ...
Antifungal Drug Discovery: New Theories and New Therapies
(2016)
Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised ...
Antibody Fc Engineering: Towards Better Therapeutics
(2018)
Monoclonal antibodies and Fc-fusion proteins used clinically are Fc-based therapeutics that grow fastest in the pharmaceutical industry. Since they both contain an Fc fragment, engineering of Fc fragments could be a platform ...
Augmentation of Brain Function: Facts, Fiction and Controversy. Volume III: From Clinical Applications to Ethical Issues and Futuristic Ideas
(2018)
The final volume in this tripartite series on Brain Augmentation is entitled “From Clinical Applications to Ethical Issues and Futuristic Ideas”. Many of the articles within this volume deal with translational efforts ...
Augmentation of Brain Function: Facts, Fiction and Controversy. Volume II: Neurostimulation and Pharmacological Approaches
(2018)
The Volume II is entitled “Neurostimulation and pharmacological approaches”. This volume describes augmentation approaches, where improvements in brain functions are achieved by modulation of brain circuits with electrical ...
Augmentation of Brain Function: Facts, Fiction and Controversy. Volume I: Brain-Machine Interfaces
(2018)
Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by ...
Advances in the Prevention and Treatment of Inflammation-Associated Preterm Birth
(2016)
After decades of intensive research and over 10,000 publications, preterm birth remains a major global obstetric healthcare problem. Each year, early birth is responsible for the deaths of more than one million infants ...
Advances in Systems Immunology and Cancer
(2014)
Aims and Scope: The Research Topic is designed to feature the latest innovative and leading-edge research, reviews and opinions on the study of complex and dynamic processes related to the mammalian immune system and cancer. ...
Arrest chemokines
(2015)
Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve ...
Astrocytic-neuronal-astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA
(2014)
Endocrinological research early recognized the importance of intercellular interactions and realized the importance of glutamatergic and GABAergic signaling. In turn this signalling depends on elaborate interactions between ...
Attention, predictions and expectations and their violation: attentional control in the human brain
(2015)
In the burdened scenes of everyday life, our brains must select from among many competing inputs for perceptual synthesis - so that only the most relevant receive full attention and irrelevant (distracting) information is ...
Attachment Assessment in treatments, prevention and intervention programs
(2015)
Attachment theory, assessment and research offers a broad, far-reaching view of human functioning, and it can enrich a psychologist's understanding of subjects and their relational adjustment, both in clinical and non-clinical ...
The Bacterial Cell: Coupling between Growth, Nucleoid Replication, Cell Division and Shape
(2016)
Bacterial Physiology was inaugurated as a discipline by the seminal research of Maaløe, Schaechter and Kjeldgaard published in 1958. Their work clarified the relationship between cell composition and growth rate and led ...
Bacterial pathogens in the non-clinical environment
(2015)
The transmission route used by many bacterial pathogens of clinical importance includes a step outside the host; thereafter refer to as the non-clinical environment (NCE). Obvious examples include foodborne and waterborne ...
Beyond the borders: The gates and fences of Neuroimmune interaction
(2014)
Neuroimmunology is a rapidly growing emerging field at which two old sciences have converged to integrate two different types of responses into a single coherent response involving the coordinated action of both systems, ...
Beyond the simple contrastive analysis: Appropriate experimental approaches for unraveling the neural basis of conscious experience
(2015)
Contrasting conditions with and without conscious experience has served consciousness research well. However, research based on this simple contrast has led to controversies about the neural basis of conscious experience. ...
Beyond the Iron Age: The ecological relevance of bioactive trace metals other than Fe and organic growth factors in aquatic systems
(2015)
In the last three decades, research has extensively focused on the role of Fe and other mineral nutrients in regulating biological processes, ranging from the surface to the deep ocean. This has produced major breakthroughs ...
Beyond the conventional Renin Angiotensin System
(2014)
It is well known that the activation of the circulating renin angiotensin system is involved in cardiovascular pathology including hypertension, heart failure and is responsible for important organic changes induced by ...
Agrobacterium biology and its application to transgenic plant production
(2015)
The broad host range pathogenic bacterium Agrobacterium tumefaciens has been widely studied as a model system to understand horizontal gene flow, secretion of effector proteins into host cells, and plant-pathogen interactions. ...
Can't Get You Out of My Head: Brain-Body Interactions in Perseverative Cognition
(2018)
Perseverative cognition is defined as the repetitive or sustained activation of cognitive representations of past stressful events or feared events in the future and even at non-clinical levels it causes a “fight-or-flight” ...
Carbohydrates: The yet to be tasted sweet spot of immunity
(2015)
Carbohydrates are extremely abundant bio-molecules; they are on all mammalian cell surfaces as well as on bacterial cell surfaces. In mammals most secreted proteins are glycosylated, with the glycan component comprising a ...
Cell Signaling in Host-Pathogen Interactions: The Host Point of View
(2018)
The ability of pathogens, such as parasites, bacteria, fungi and viruses to invade, persist and adapt in both invertebrate and vertebrate hosts is multifactorial and depends on both pathogen and host fitness. Communication ...
Cell Fate
(2016)
The fundamental question of how an undifferentiated progenitor cell adopts a more specialized cell fate that then contributes to the development of specialized tissues, organs, organ systems and ultimately a unique individual ...
Cell Stress, Metabolic Reprogramming, and Cancer
(2018)
The present eBook presents one review, five mini-reviews, and an opinion article on the achievements and perspectives of studies on important aspects of cancer cell metabolic reprogramming whose mechanisms and regulation ...
Apoptotic Cell Clearance in Health and Disease
(2018)
Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of ...
Application of Antigen Cross-Presentation Research into Patient Care
(2017)
The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of ...
Advances in Plastid Biology and Its Applications
(2016)
One of the distinguishing features of plants is the presence of membrane-bound organelles called plastids. Starting from proplastids (undifferentiated plastids) they readily develop into specialised types, which are involved ...
Advances in Plant-Hemipteran Interactions
(2017)
Hemipterans encompass a large group of insect pests of plants that utilize mouthparts which are modified for piercing and consuming fluids from plants. In addition, hemipterans vector viral and bacterial diseases of plants. ...
Artificial Neural Networks as Models of Neural Information Processing
(2018)
Modern neural networks gave rise to major breakthroughs in several research areas. In neuroscience, we are witnessing a reappraisal of neural network theory and its relevance for understanding information processing in ...
Associations between Reading and Mathematics: Genetic, Brain Imaging, Cognitive and Educational Perspectives
(2017)
Converging evidence demonstrates a strong link between reading and mathematics: multiple cognitive processes are shared between reading and mathematics, including the representation and retrieval of symbolic information, ...
The Association of Other Autoimmune Diseases in Patients With Thyroid Autoimmunity
(2018)
Autoimmune thyroid diseases (AITD) are T cell-mediated organ-specific autoimmune disorders resulting from an immune dysregulation leading to a thyroid immune attack (Antonelli and Benvenga). Graves’ disease and Hashimoto’s ...
Cancer Nanotheranostics: What Have We Learned So Far?
(2016)
After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the ...
Cancer Metabolism: Molecular Targeting and Implications for Therapy
(2017)
Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular ...
Cancer Immunotherapy & Immuno-monitoring: Mechanism, Treatment, Diagnosis, and Emerging Tools
(2014)
In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, ...