Publications
Now showing items 881-920 of 1372
Parkinson's Disease Cell Vulnerability and Disease Progression
(2015)
Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars ...
Patient Engagement in Health and Well-Being: Theoretical and Empirical Perspectives in Patient Centered Medicine
(2018)
At present citizens are more aware of their health and care rights and more literate about their disease. Furthermore the continuous development of technological and bio-medical solutions are alimenting the expectation for ...
Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic
(2017)
The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control ...
Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
(2015)
Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including ...
Pathophysiology and epidemiology of virus-induced asthma
(2015)
Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines ...
Physical Activity, Self-Regulation, and Executive Control Across the Lifespan
(2016)
There is overwhelming evidence linking increased physical activity with positive changes in cognitive functioning and brain health. Much of what we know about these interrelationships comes from aerobic exercise training ...
New Models of Care for Patients with Severe Mental Illness - Bridging In- and Outpatients
(2018)
Over the past years, psychiatric services have been continuously faced with the challenge of providing comprehensive care to people suffering from severe mental illnesses. Legal and conceptual advances like the UN convention ...
Novel clinical applications of extracellular vesicles
(2015)
During the last years, the research on extracellular vesicles (EVs) has raised giving new insights into pathophysiology of several diseases. EVs are membrane-bound particles secreted by almost all cell types. Depending on ...
Novel insights in rehabilitation of neglect, 2nd Edition
(2015)
Hemispatial neglect is the failure to report, respond to, or orient to novel or meaningful stimuli presented in the contralesional visual field. It constitutes one of the most invalidating neurological disorders that can ...
Mathematics for Healthcare
(2018)
In 1996, and with extraordinary prescience, Panfilov and Holden had highlighted in their seminal book 'Computational Biology of the Heart' that biology was, potentially, the most mathematical of all sciences. Fast-forward ...
An Open Book: What and How Young Children Learn From Picture and Story Books
(2016)
Looking at and listening to picture and story books is a ubiquitous activity, frequently enjoyed by many young children and their parents. Well before children can read for themselves they are able to learn from books. ...
Optimizing Exercise for the Prevention and Treatment of Type 2 Diabetes
(2018)
This eBook contains a collection of peer-reviewed original and review articles published in either Frontiers in Endocrinology or Frontiers in Physiology focused on the research topic Optimizing Exercise for the Prevention ...
Pediatric Hypertension: Update
(2018)
Hypertension and its resultant complications do occur in childhood and track into adulthood. It’s estimated that > 3% of all children have hypertension, with an even greater prevalence among obese children (20-47%). The ...
Pediatric Venous Thromboembolism
(2018)
Venous thromboembolism (VTE) occurs less often in children than adults and therefore remains underrecognized despite increasing in incidence. Due to the risk of mortality, short- and long-term morbidity, and increased ...
People - Marine Mammal Interactions
(2017)
Our relationships with marine mammals are complex. We have used them as resources, and in some places this remains the case; viewed them as competitors and culled them (again ongoing in some localities); been so captivated ...
Perivascular Adipose Tissue (PVAT) in Health and Disease
(2018)
In 1991, Soltis and Cassis (Clin Exp Hypertens A 1991 13:277-296) published the first paper that the fat tissue around an artery – perivascular adipose tissue or PVAT – changed how the artery contracted to norepinephrine. ...
Overlap of Neural Systems for Processing Language and Music
(2016)
The interplay between musical training and speech perception continues to intrigue researchers in the areas of language and music alike. Historically, language function has been attributed to brain regions localized ...
Palynology and Vegetation History
(2019)
This Research Topic commemorates the centenary of the first quantitative pollen diagram by Lennart von Post, the founder of paleoecological palynology. The main aim is to provide a thorough view of the use of palynology ...
Parenthood From Biology to Relation. Prevention, Assessment and Interventions for Developmental and Clinical Issues
(2018)
Parenthood represents a fundamental construct that identifies the quality of early adult-infant interactions. In both short and long period, relationships, as primary interactional experiences, have an essential role in ...
The Philosophy of Psychiatry and Biologism
(2014)
There has been an ongoing debate about the capabilities and limits of the bio-natural sciences as sources and the methodological measure in the philosophy of psychiatry for quite some time now. Still, many problems remain ...
The Physiological Functions of the Amyloid Precursor Protein Gene Family
(2017)
The amyloid precursor protein APP plays a key role in the pathogenesis of Alzheimer’s disease (AD), as proteolytical cleavage of APP gives rise to the Aß peptide which is deposited in the brains of Alzheimer patients. ...
Physiological and molecular ecology of aquatic cyanobacteria
(2015)
The cyanobacteria inhabit every illuminated environment on Earth, from polar lakes to desert crusts and through their phototrophic metabolism play essential roles in global geochemical cycles. With the discovery of marine ...
Physiological Adaptations to Swimming in Fish
(2017)
Swimming is an integral part of the life history of many fish species as is intimately linked with their ability to express feeding and predator avoidance behaviors, habitat selection and environmental preferences, social ...
Planctomycetes-Verrucomicrobia-Chlamydiae Bacterial Superphylum: New Model Organisms for Evolutionary Cell Biology
(2017)
The Planctomycetes, Verrucomicrobia, Chlamydiae (PVC) and related phyla have recently emerged as fascinating subjects for research in evolutionary cell biology, ecology, biotechnology, evolution and human health. This ...
New edge of antibiotic development: antimicrobial peptides and corresponding resistance
(2014)
Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal ...
New Trends on Genome and Transcriptome Characterizations
(2018)
This Research Topic is devoted to bioinformaticians, geneticists and researchers who study or apply methods and algorithms for genomes and transcriptome analyses, aimed at understanding pathology discriminations and ...
Mathematical and Statistics Anxiety: Educational, Social, Developmental and Cognitive Perspectives
(2017)
Mathematical anxiety is a feeling of tension, apprehension or fear which arises when a person is faced with mathematical content. The negative consequences of mathematical anxiety are well-documented. Students with high ...
Platelets as immune cells in physiology and immunopathology
(2015)
Are platelets cells? (Not everyone agrees, since they are non-nucleate). And if platelets are cells - which all specialists consider at the time being - are they immune cells? The issue that platelets participate in immunity ...
Plastid Proteostasis: Relevance of Transcription; Translation and Post-Translational Modifications
(2017)
Due to their bacterial endosymbiotic origin plastids are organelles with both nuclear-encoded and plastid-encoded proteins. Therefore, a highly integrated modulation of gene expression between the nucleus and the plastome ...
Plasticity of primary afferent neurons and sensory processing after spinal cord injury
(2015)
Traumatic injury of the spinal cord affects the entire organism directly and indirectly. Primary injury destroys neurons and severs axons which participate in neural circuits. Secondary injuries and pathologies arise from ...
Plasticity of GABAergic synapses
(2016)
Learning and memory are believed to depend on plastic changes of neuronal circuits due to activity-dependent potentiation or depression of specific synapses. During the last two decades, plasticity of brain circuits was ...
Optical Approaches to Capture Plant Dynamics in Time, Space, and Across Scales
(2018)
Quantifying temporal changes in plant geometry as a result of genetic, developmental, or environmental causes is essential to improve our understanding of the structure and function relationships in plants. Over the last ...
The oral microbiome in an ecological perspective
(2015)
The oral cavity harbors an immense diversity of microorganisms, including bacteria, fungi, archaea, protozoa and viruses. At health, oral microbial community is thought to be in a state of homeostasis, even after numerous ...
Perceiving and Acting in the Real World: From Neural Activity to Behavior
(2016)
One remarkable ability of the human brain is to process large amounts of information about our surroundings to allow us to interact effectively with them. In everyday life, the most common way to interact with objects is ...
Perception of visual advertising in different media: from attention to distraction, persuasion, preference and memory
(2015)
This Research Topic aims to showcase the state of the art in visual advertising research. Although visual processes are a central component of consumer behavior, they have been largely neglected in models explaining consumer ...
Perception and Cognition: Interactions in the Ageing Brain
(2016)
Healthy ageing can lead to declines in both perceptual and cognitive functions. Impaired perception, such as that resulting from hearing loss or reduced visual or tactile resolution, increases demands on ‘higher-level’ ...
Personalized Medicine and Neurosurgery
(2017)
The Precision Medicine Initiative, which was instituted by President Barack Obama on January 20, 2015, highlighted the importance that advances in genomics and related “-omic” approaches have made to science and medicine, ...
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system
(2015)
The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. ...
The Origin of the Plasma Cell Heterogeneity
(2015)
Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve ...
Paradigm changes are required in HIV vaccine research
(2015)
In his 1962 book "The Structure of Scientific Revolutions", Thomas Kuhn famously argued that researchers in every field of scientific enquiry always operate under a set of presuppositions known as paradigms that are rarely ...