Publications
Now showing items 481-500 of 1372
Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity
(2016)
Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms ...
Host-adapted metabolism and its regulation in Bacterial Pathogens
(2015)
Pathogens adapt their metabolism rapidly to the host. Our topic covers these phenomenon regarding extracellular and intracellular pathogens as well as general methods to elucidate different metabolic adaptation processes ...
How Humans Recognize Objects: Segmentation, Categorization and Individual Identification
(2016)
Human beings experience a world of objects: bounded entities that occupy space and persist through time. Our actions are directed toward objects, and our language describes objects. We categorize objects into kinds that ...
How nature shaped echolocation in animals
(2014)
Echolocation has evolved in different groups of animals, from bats and cetaceans to birds and humans, and enables localization and tracking of objects in a dynamic environment, where light levels may be very low or absent. ...
How Salmonella infection can inform on mechanisms of immune function and homeostasis
(2016)
The use of model antigens such as haptens and ovalbumin has provided enormous insights into how immune responses develop, particularly to vaccine antigens. Furthermore, these studies are overwhelmingly performed in animals ...
How Fear and Stress Shape the Mind
(2016)
The experience of fear and stress leaves an indelible trace on the brain. This indelible trace is observed as both changes in behavior and changes in neuronal structure and function. Fear and stress interact on many levels. ...
Hypoxia in Kidney Disease
(2018)
Kidney disease is a complex health problem, often coinciding with cardiovascular pathology (e.g. hypertension) and metabolic disturbances (e.g. obesity and diabetes). It is also a disturbingly fast growing global public ...
ICT for assessment and rehabilitation in Alzheimer's disease and related disorders
(2016)
Information and Communication Technologies (ICT) are no longer objects gathering dust on a shelf; instead, they have become intrinsic in our everyday lives. They are now even taking on an indispensable role in many clinical ...
Immune Checkpoint Molecules and Cancer Immunotherapy
(2019)
For the faultless function of the immune system, tight regulation of immune cell activation, immuno-suppression and the strength and efficiency of the immune response is essential. Immune checkpoint (ICP) molecules can ...
Immune Interactions during the Reproductive Cycle
(2015)
Mammalian pregnancy represents a unique immunological riddle in that the mother does not reject her allogeneic fetus. In part this is largely due to a general sequestration or diminution of T cell activity, and an increased ...
Immune responses to AAV vectors, from bench to bedside
(2015)
The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years ...
Immune-Epithelial Crosstalk in Inflammatory Bowel Diseases and Mucosal Wound Healing
(2018)
80% of the bodies’ immune cells are harbored within the intestine. They are only separated from 1014 microorganisms by a single layer of intestinal epithelial cells and a secreted superficial mucus layer. Therefore, the ...
Immune System Modeling and Analysis
(2015)
The rapid development of new methods for immunological data collection - from multicolor flow cytometry, through single-cell imaging, to deep sequencing - presents us now, for the first time, with the ability to analyze ...
Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes
(2017)
The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the ...
Impact of Diet on Learning, Memory and Cognition
(2017)
Changes in food composition and availability have contributed to the dramatic increase in obesity over the past 30-40 years in developed and, increasingly, in developing countries. The modern diet now contains many foods ...
The impact of learning to read on visual processing
(2016)
Reading is at the interface between the vision and spoken language domains. An emergent bulk of research indicates that learning to read strongly impacts on non-linguistic visual object processing, both at the behavioral ...
Improving Animal Welfare through Genetic Selection
(2016)
In livestock species, breeding goals are aimed primarily at improvement of production traits. However, there are a number of examples where selection for high production efficiency has resulted in reduced welfare through ...
In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration
(2016)
The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. ...
In Vivo Imaging in Pharmacological Research
(2017)
The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a ...
Individual Differences: From Neurobiological Bases to New Insight on Approach and Avoidance Behavior
(2016)
The superordinate division of emotions is distributed along a bipolar dimension of affective valence, from approaching rewarding situations to avoiding punitive situations. Avoiding and approaching behaviors determine the ...