Publications
Now showing items 521-540 of 1372
The Impact of Systems Medicine on Human Health and Disease
(2017)
Complex diseases including diabetes, neurological disorders and cancer are results from a combination of genetic, environmental and lifestyle factors, and development of new prognostic tools for the treatment of such ...
The Impact of Sensory; Linguistic and Social Deprivation on Cognition
(2017)
Early experience plays a crucial role in determining the trajectory of cognitive development. For example, early sensory deprivation is known to induce neural reorganization by way of adaptation to the altered sensory ...
The Importance of Iron in Pathophysiologic Conditions
(2015)
The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain ...
Improving Bayesian Reasoning: What Works and Why?
(2016)
We confess that the first part of our title is somewhat of a misnomer. Bayesian reasoning is a normative approach to probabilistic belief revision and, as such, it is in need of no improvement. Rather, it is the typical ...
Improving Working Memory in Learning and Intellectual Disabilities
(2016)
The last forty years of research have demonstrated that working memory (WM) is a key concept for understanding higher-order cognition. To give an example, WM is involved in reading comprehension, problem solving and ...
Improving outcomes in cerebral palsy with early intervention: new translational approaches
(2015)
The aim of this Research Topic was to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials ...
Industrial and Host Associated Stress Responses in Food Microbes. Implications for Food Technology and Food Safety
(2017)
Throughout the food processing chain and after ingestion by the host, food associated bacteria have to cope with a range of stress factors such as thermal and/or non-thermal inactivation treatments, refrigeration temperatures, ...
Inflammation in the CNS: Advancing the Field Using Intravital Imaging
(2017)
Inflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses ...
Inferior Colliculus Microcircuits
(2015)
The inferior colliculus (IC) is a unique structure in the auditory system, located between the primary auditory nuclei of the brainstem and the thalamus. The existence of the complex neural circuits in the auditory brainstem ...
Information-based methods for neuroimaging: analyzing structure, function and dynamics
(2015)
The aim of this Research Topic is to discuss the state of the art on the use of Information-based methods in the analysis of neuroimaging data. Information-based methods, typically built as extensions of the Shannon Entropy, ...
Inhibitory Function in Auditory Processing
(2015)
There seems little doubt that from the earliest evolutionary beginnings, inhibition has been a fundamental feature of neuronal circuits - even the simplest life forms sense and interact with their environment, orienting ...
Inhibiting PARP as a Strategic Target in Cancer
(2016)
Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant ...
How and Why Does Spatial-Hearing Ability Differ among Listeners? What Is the Role of Learning and Multisensory Interactions?
(2016)
Spatial-hearing ability has been found to vary widely across listeners. A survey of the existing auditory-space perception literature suggests that three main types of factors may account for this variability: - physical ...
How aging affects T lymphocyte-mediated immunity
(2015)
Increasing age has been associated with an insufficient protection following vaccination and an increased incidence and severity of infectious diseases. The predicted acceleration of global population aging will accentuate ...
The HSP70 Molecular Chaperone Machines
(2017)
Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form ...
How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation?
(2015)
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative ...
HSPs - Ambiguous Mediators of Immunity
(2017)
Heat shock proteins (HSPs) were discovered as polypeptides induced by stress that can be found in all kingdoms of cellular organisms. Their functions were, a first enigmatic and these proteins were thus classified by ...
Hybrid Solutions for the Modelling of Complex Environmental Systems
(2017)
Systems studied in environmental science, due to their structure and the heterogeneity of the entities composing them, often exhibit complex dynamics that can only be captured by hybrid modeling approaches. While several ...
Abiotic Stresses in Agroecology: A Challenge for Whole Plant Physiology
(2017)
Understanding plant responses to abiotic stresses is central to our ability to predict the impact of global change and environmental pollution on the production of food, feed and forestry. Besides increasing carbon dioxide ...