Publications
Now showing items 1121-1160 of 1372
Regulation of Inflammation; Its Resolution and Therapeutic Targeting
(2018)
Inflammation is a fundamental protective mechanism and at the same time the driving force of a variety of major diseases in humans. Indeed, acute self-resolving inflammation usually plays a positive role for the host, as ...
Regulation of Tissue Responses: The TWEAK/Fn14 Pathway and other TNF/ TNFR Superfamily Members that Activate Noncanonical NFkB Signaling
(2016)
The immune system mediates tissue responses under both physiological and pathological conditions, impacting the inflammatory, fibrogenic and regenerative components. In addition to various leukocyte subsets, it is now ...
Regulation of immune system cell functions by protein kinase C
(2014)
Members of the protein kinase C (PKC) family of Ser/Thr kinases are encoded by nine distinct but closely related genes, which give rise to more than 12 different protein isoforms via a mechanism of alternative RNA splicing. ...
Regulation of Endurance Performance: New Frontiers
(2017)
Successful endurance performance requires the integration of multiple physiological and psychological systems, working together to regulate exercise intensity in a way that will reduce time taken or increase work done. The ...
Regulation of red cell life-span, erythropoiesis, senescence and clearance
(2014)
Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell ...
Relevance of Translational Regulation on Plant Growth and Environmental Responses
(2018)
Plants, as sessile organisms, are exposed to a large array of challenging external and internal alterations that may restrict plant growth. These limiting growth conditions activate plant signalling responses which eventually ...
Repetitive Structures in Biological Sequences: Algorithms and Applications
(2016)
Repetitive structures in biological sequences are emerging as an active focus of research and the unifying concept of "repeatome" (the ensemble of knowledge associated with repeating structures in genomic/proteomic sequences) ...
Recent advances in Pancreatology
(2014)
Pancreatic diseases include intractable ones including acute and chronic pancreatitis, and pancreatic cancer. In recent years, great advances have been made in the field of pancreatology, including the pathogenesis, ...
Recent advances and the future generation of neuroinformatics infrastructure
(2015)
The huge volume of multi-modal neuroimaging data across different neuroscience communities has posed a daunting challenge to traditional methods of data sharing, data archiving, data processing and data analysis. ...
Rio, Tokyo Paralympic Games and beyond: How to Prepare Athletes with Motor Disabilities for Peaking
(2017)
In 1960, the 9th Annual International Stoke Mandeville Games were supported, for the first time, by the Italian Olympic Committee. Taking place six days after the Closing Ceremony of the XVII Olympic Games, the paralympic ...
Role of Health Economic Data in Policy Making and Reimbursement of New Medical Technologies
(2017)
This Research Topic was focused on provision of novel medical technologies worldwide keeping in mind financial sustainability challenge. An exemplary area certainly are oncology pharmaceuticals where prices have increased ...
The Role of Glia in Plasticity and Behavior
(2015)
Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function ...
Role of lipids in virus assembly
(2015)
RNA enveloped viruses comprise several families belonging to plus and minus strand RNA viruses, such as retroviruses, flavoviruses and orthomyxoviruses. Viruses utilize cellular lipids during critical steps of replication ...
Role of Intravenous Levetiracetam in Acute Seizure Management
(2014)
Intractable epilepsy still remains the main issue despite new advances in medical and surgical treatment of epilepsy. Acute seizure management in a timely manner is crucial to prevent irreversible brain damage. Benzodiazepines ...
The Role of Iron in Bacterial Pathogenesis
(2018)
The collection of articles published in this eBook represent different facets of the interactions between pathogens and their host concerning the battle for iron. Pathogens have developed different strategies to acquire ...
Representation in the Brain
(2018)
This eBook contains ten articles on the topic of representation of abstract concepts, both simple and complex, at the neural level in the brain. Seven of the articles directly address the main competing theories of mental ...
School Achievement and Failure in Portuguese and Spanish Speaking Countries
(2018)
This book is devoted to an increasingly important educational problem in the modern societies: school achievement and failure. School failure is presently a problem in developed as well as in developing countries. In the ...
Sea Level Variability and Change
(2017)
In June 2015 we held a workshop on the beautiful island of Mallorca, Spain with a focus on sea level variability and change. Over 120 sea level experts from around the world attended this workshop, from a range of different ...
Sedentary Behaviour in Human Health and Disease
(2018)
Sedentary behaviour – too much sitting as distinct from too little physical activity – is now recognised as an independent risk factor for several health outcomes and premature mortality. This is problematic as technological ...
Self-Organization in the Nervous System
(2017)
This special issue reviews state-of-the-art approaches to the biophysical roots of cognition. These approaches appeal to the notion that cognitive capacities serve to optimize responses to changing external conditions. ...
Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy
(2018)
Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An ...
Sensory Hair Cell Death and Regeneration
(2016)
Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. ...
Signalling Pathways in Embryonic Development
(2017)
The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells ...
Significance of antigen and epitope specificity in tuberculosis
(2014)
Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of ...
Smelly Fumes: Volatile-Mediated Communication between Bacteria and Other Organisms
(2017)
This e-book summarizes recent advances in the young and rapidly developing field of microbial volatiles. Articles included here reveal novel information about the chemical diversity of bacterial and fungal volatiles, their ...
Social Hormones and Human Behavior: What Do We Know and Where Do We Go from Here
(2015)
Oxytocin (OT) and arginine vasopressin (AVP) are the paramount social hormones in mammals and accumulating evidence also strengthens the unique role of these neuropeptides also in human social behavior. Indeed from voles ...
Preclinical and clinical issues in Alzheimer's disease drug research and development
(2015)
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the ...
Precision Public Health
(2018)
Precision Public Health is a new and rapidly evolving field, that examines the application of new technologies to public health policy and practice. It draws on a broad range of disciplines including genomics, spatial data, ...
The state of the art in student engagement
(2015)
There is an extensive literature conducted from a range of theoretical perspectives and methodologies on the role of groups and student learning in higher education. However here the concept of the ‘group’ is heavily ...
Stem cells and progenitor cells in ischemic stroke - fashion or future?
(2016)
Stroke remains one of the most devastating diseases in industrialized countries. Recanalization of the occluded arterial vessel using thrombolysis is the only causal therapy available. However, thrombolysis is limited due ...
Serotonin and Memory
(2016)
The study of 5-hydroxytryptamine (5-HT) systems has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Increasing evidence suggests that 5-HT pathways, reuptake ...
Roles and mechanisms of parasitism in aquatic microbial communities
(2015)
Next Generation Sequencing technologies are increasingly revealing that microbial taxa likely to be parasites or symbionts are probably much more prevalent and diverse than previously thought. Every well studied free-living ...
The Roles of GnIH in Reproductive Function and Behavior
(2018)
Since the discovery of gonadotropin-releasing hormone (GnRH) at the beginning of 1970s, it has been believed that GnRH is the only hypothalamic neuropeptide that regulates gonadotropin release in vertebrates. In 2000, ...
The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders
(2015)
Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be ...
Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond
(2018)
Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading ...
Salinity Tolerance in Plants: Mechanisms and Regulation of Ion Transport
(2018)
Life presumably arose in the primeval oceans with similar or even greater salinity than the present ocean, so the ancient cells were designed to withstand salinity. However, the immediate ancestors of land plants most ...
Salicylic Acid Signaling Networks
(2016)
The small phenolic compound salicylic acid (SA) is critical for plant defense against a broad spectrum of pathogens. SA is also involved in multi-layered defense responses, from pathogen-associated molecular pattern triggered ...
Single Membrane Channels Formed by Connexins or Pannexins: Focus on the Nervous System
(2016)
Given that the extremely elaborated and dynamic functions performed by the nervous system require the close synchronization of brain cells, complex organisms have developed different mechanisms of intercellular communication. ...
Social Cognition, Motivation, and Interaction How Do People Respond to Threats in Social Interactions?
(2018)
f we want to understand people’s responses to threats in social interactions we can distinguish between three levels of analysis:On a social level of analysis we can describe people’s interpersonal behavior, on a cognitive ...
Stem Cell Genetic Fidelity
(2015)
The vision of this Frontiers in Oncology Research Topic on "Stem Cell Genetic Fidelity" had the goal of steeping a diverse range of research perspectives to a first comprehensive synthesis of thought on the questions of ...