Publications
Now showing items 121-180 of 1372
Cerebral endothelial and glial cells are more than bricks in the Great Wall of the brain: Insights into the way the blood-brain barrier actually works (Celebrating the centenary of Goldman's experiments)
(2015)
When Ehrlich discovered the first evidence of the blood-brain barrier in 1885, he probably did not perceive the Great Wall that remained hidden from consciousness inside the central nervous system. Ehrlich had observed ...
Cerebral oxygenation in health and disease
(2015)
Scientists and clinicians interested in cerebrovascular physiology in humans now have numerous possibilities to monitor, invasively or non-invasively, the oxygenation status of cerebral tissue. Monitoring cerebral oxygenation ...
The Cerebellum: From Development to Learning
(2015)
In this book, laboratory leaders on cerebellar neuroscience have revised the present body of knowledge about cerebellum anatomy and function. The trip throughout the cerebellar vineyard organization starts from the causal ...
Biological Engagement Programs: Reducing Threats and Strengthening Global Health Security Through Scientific Collaboration
(2017)
Biological engagement programs are a set of projects or activities between partner countries that strengthen global health security to achieve mutually beneficial outcomes. Engagement programs are an effective way to work ...
Biological Ontologies and Semantic Biology
(2014)
As the amount of biological information and its diversity accumulates massively there is a critical need to facilitate the integration of this data to allow new and unexpected conclusions to be drawn from it. The Semantic ...
Biological Hazards in Food
(2017)
The ingestion of food containing pathogenic microorganisms (i.e. bacteria and their toxins, fungi, viruses) and parasites can cause food-borne diseases in humans. A growing number of emerging pathogens, changes of virulence ...
Biotrophic Plant-Microbe Interactions
(2017)
Throughout their life, plants interact with all sorts of microbes. Some of these are detrimental and cause disease; some interactions are mutually beneficial for both partners. It is clear that most, if not all, of the ...
Biotechnology of Microalgae, Based on Molecular Biology and Biochemistry of Eukaryotic Algae and Cyanobacteria
(2017)
Bioechnology of microalgae takes much attention because of their ability to utilize light energy and fix CO2. Research in biotechnology of microalgae including eukaryotic algae and cyanobacteria is an important and attractive ...
Charophytes: Evolutionary Ancestors of Plants and Emerging Models for Plant Research
(2017)
The charophytes are the group of green algae that are anestral and most closely related to land plants. Today, these organisms are not only important in evoutionary studies but have become outstanding model organisms for ...
Computational Systems Biology of Pathogen-Host Interactions
(2016)
A thorough understanding of pathogenic microorganisms and their interactions with host organisms is crucial to prevent infectious threats due to the fact that Pathogen-Host Interactions (PHIs) have critical roles in ...
Character, Responsibility, and Well-Being: Influences on Mental Health and Constructive Behavior Patterns
(2016)
Character can be defined as self-aware knowledge that helps the individual to set goals, values and ethical principles (Cloninger, 2004). This meta-cognitive dimension of human personality involves ‘Theory of Mind’, and ...
The biology and ecology of ticks shape the potential for the transmission of zoonotic pathogens
(2015)
Ticks are noticeable by the high diversity of pathogens they can transmit, most of them with implications in human and animal health. Ticks are arachnids, meaning that they do not share the biological and ecological features ...
Biology and Pathogenesis of Legionella
(2018)
Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant ...
Biology of Brain Disorders
(2018)
Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic ...
Biosignal processing and computational methods to enhance sensory motor neuroprosthetics
(2016)
Though there have been many developments in sensory/motor prosthetics, they have not yet reached the level of standard and worldwide use like pacemakers and cochlear implants. One challenging issue in motor prosthetics is ...
Breaking the cycle: Attacking the malaria parasite in the liver
(2015)
Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African ...
The Coming of Age of Insulin-Signalling in Insects
(2015)
The new millennium has seen a major paradigm shift in insect endocrinology. Great advancements are being made which establish that nutrition and growth play a central role in diverse cellular and physiological phenomena ...
A comparative survey of the RF-amide peptide superfamily
(2015)
The discovery, twelve years ago, that the RF-amide peptide kisspeptin, acting via GPR54, is essential for the onset of puberty and reproduction, has been a major breakthrough in reproductive physiology. It has also put in ...
Comparative studies between HTLV-1 and HTLV-2 function and pathobiology
(2015)
Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly ...
Comparative Studies of Energy Homeostasis in Vertebrates
(2018)
A brief glimpse into new insight driving the comparative biology of energy homeostasis in vertebrates with a focus on non-mammalian vertebrates. What are the key conserved mechanisms and what aspects of feeding behavior ...
Computational and Experimental Approaches in Multi-Target Pharmacology
(2017)
The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target ...
Control of Visceral Leishmaniasis by Immunotherapeutic and Prophylactic Strategies
(2015)
Visceral leishmaniasis (VL) or kala-azar is the most dreadful of all forms of leishmaniasis caused by Leishmania donovani in Old World and Leishmania chagasi and/or Leishmania infantum in New World affecting millions of ...
Control of Pestivirus Infections in the Management of Wildlife Populations
(2016)
Infections with recognized and putative species of the genus pestivirus are not host-specific and are documented in many wildlife species. The study of pestivirus infections in wildlife species is important both to eradication ...
Crop Traits for Defense against Pests and Disease: Durability, Breakdown and Future Prospects
(2017)
With global populations expected to exceed 9.2 billion by 2050 and available land and water resources devoted to crop production dwindling, we face significant challenges to secure global food security. Only 12 plant species ...
Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer
(2017)
Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph ...
Current challenges in photosynthesis: From natural to artificial
(2014)
Jules Verne (1828-1905), author of Around the World in Eighty Days (1873) and Journey to the Center of the Earth (1864), wrote in 1875: "I believe that water will one day be used as a fuel, because the hydrogen and oxygen ...
Current Challenges and Future Perspectives on Emerging Bioelectrochemical Technologies
(2016)
The increasing demand for energy worldwide, currently evaluated at 13 terawatts per year, has triggered a surge in research on alternative energy sources more sustainable and environmentally friendly. Bio-catalyzed ...
Current Challenges in Cardiovascular Molecular Diagnostics
(2017)
The field of cardiovascular genetics has tremendously benefited from the recent application of massive parallel sequencing technology also referred to as next generation sequencing (NGS). However, along with the discovery ...
Current Challenges in Modeling Cellular Metabolism
(2016)
Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict ...
Dementia, Frailty and Aging
(2018)
The number of older subjects is rapidly increasingly worldwide. As a consequence, the nature of clinical conditions is also changing. Traditional medicine and models of care have been based on the evaluation and treatment ...
Bioactive Compounds from Microbes
(2017)
Microorganisms have had a long and surprising history. They were “invisible” until invention of microscope in the 17th century. Until that date, although they were extensively (but inconsciously) employed in food preservation, ...
Brain and Art
(2014)
Could we understand, in biological terms, the unique and fantastic capabilities of the human brain to both create and enjoy art? In the past decade neuroscience has made a huge leap in developing experimental techniques ...
Brief Interventions for Risky Drinkers
(2016)
Alcohol is the sixth leading risk factor for disability and premature death all over the world, and one of the leading causes of premature mortality in western societies; it is a leading risk factor for death in young and ...
Bridging the Gap Between Policy and Science in Assessing the Health Status of Marine Ecosystems, 2nd Edition
(2017)
Marine management requires approaches which bring together the best research from the natural and social sciences. It requires stakeholders to be well-informed by science and to work across administrative and geographical ...
Bridging the Theories of Affordances and Limb Apraxia
(2017)
Affordances are meaningful relations between the features of observed objects and the observer's action systems with its proper abilities. The notion of affordance integrates perceptual, cognitive and motor functions, so ...
Children and Companion Animals: Psychosocial, Medical, and Neurobiological Implications
(2018)
Children and companion animals seem to have a natural affinity towards each other. Most children desire a relationship with their own companion animals or at least demonstrate an interest to interact with animals in general. ...
Conflict and Cooperation in Microbial Societies
(2017)
The most evident aspect of biodiversity is the variety of complex forms and behaviors among organisms, both living and extinct. Comparative molecular and physiological studies show that the evolution of complex phenotypic ...
Consciousness and Action Control
(2014)
The basic nuts and bolts underlying human behavior remain mysterious from a scientific point of view. Everyday acts - naming an object, suppressing the urge to say something, or grabbing a waiter’s attention with a ...
Corporate Social Responsibility and Organizational Psychology: Quid pro Quo
(2017)
Researchers, corporate leaders, and other stakeholders have shown increasing interest in Corporate Social Responsibility (CSR)—a company’s discretionary actions and policies that appear to advance societal well-being beyond ...
Creativity and Mental Imagery
(2016)
Creativity is increasingly attracting attention of scientific community given its role in different aspects of human life. So far we have only began to understand its complexity and how it correlates with other cognitive ...
Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other?
(2016)
Somatic stem cells reside in definite compartments, known as “niches”, within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the ...
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges
(2017)
The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a ...
Bone Marrow Adipose Tissue: Formation; Function; and Impact on Health and Disease
(2017)
Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at ...
Bone Marrow T Cells at the Center Stage in Immunological Memory
(2017)
Increasing evidence supports the notion that bone marrow (BM) represents a relevant player in T cell responses, particularly in its role as a specialized organ for long-term memory. Memory T cells are enriched in the BM ...
The Brassicaceae Agri-Horticultural and Environmental Perspectives
(2018)
This Frontiers Research Topic "The Brassicaceae- Agri-Horticultural and Environmental Perspectives" is an effort to provide a common platform to agronomists, horticulturists, plant breeders, plant geneticists/molecular ...
Computational Methods for Understanding Complexity: The Use of Formal Methods in Biology
(2016)
The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there ...
Building the gateway to consciousness - about the development of the thalamus
(2015)
Since years, patterning and function of some brain parts such as the cortex in the forebrain and the optical tectum or cerebellum in the midbrain/hindbrain region are under strong investigation. Interestingly the diencephalon ...
Cortico-cortical Communication Dynamics
(2014)
Neurons communicate by sending action potentials down their axons and release neurotransmitter at the synapses with target neurons in nearby or remote regions. Although we know the approximate connectivity of cortico-cortical ...
Critical Earthquake Response of Elastic-Plastic Structures Under Near-Fault Ground Motions: Closed-Form Approach via Impulse Input
(2016)
The specialty section Earthquake Engineering is one branch of Frontiers in Built Environment and welcomes critical and in-depth submissions on earthquake ground motions and their effects on buildings and infrastructures. ...
Criticality as a signature of healthy neural systems: multi-scale experimental and computational studies
(2015)
Since 2003, when spontaneous activity in cortical slices was first found to follow scale-free statistical distributions in size and duration, increasing experimental evidences and theoretical models have been reported in ...
Critical Earthquake Response of Elastic-Plastic Structures and Rigid Blocks under Near-Fault Ground Motions: Closed-Form Approach via Double Impulse
(2016)
This eBook is the second in a series of books on the critical earthquake response of elastic-plastic structures or rigid blocks under near-fault ground motions, and includes four original research papers which were published ...
Continuous Quality Improvement - Advancing Understanding of Design, Application, Impact and Evaluation of CQI Approaches
(2017)
Continuous Quality Improvement (CQI) methods are increasingly widely used to bridge the gaps between the evidence base for best clinical practice, what actually happens in practice, and the achievement of better population ...
Biofilms from a Food Microbiology Perspective: Structures, Functions and Control Strategies
(2017)
Materials and equipment in food processing industries are colonized by surface-associated microbial communities called biofilms. In these biostructures microorganisms are embedded in a complex organic matrix composed ...
Biofilm formation by staphylococci and streptococci: Structural, functional and regulatory aspects and implications for pathogenesis
(2015)
Members of the genus Staphylococcus and Streptococcus are the causative agnets of many human and animal diseases. Over the past decade the complete sequencing of many staphylococcal and streptococcal genomes has promoted ...
Biomaterials and Bioactive Molecules to Drive Differentiation in Striated Muscle Tissue Engineering
(2016)
Tissue engineering is an innovative, multidisciplinary approach which combines (bio)materials, cells and growth factors with the aim to obtain neo-organogenesis to repair or replenish damaged tissues and organs. The ...
Branching and Rooting Out with a CT Scanner: The Why, the How, and the Outcomes, Present and Possibly Future
(2016)
Until recently, a majority of the applications of X-ray computed tomography (CT) scanning in plant sciences remained descriptive; some included a quantification of the plant materials when the root-soil isolation or ...
Brain-Mind-Body Practice and Health
(2018)
It is acknowledged that practice could induce rapid change or reorganization of the brain’s cellular or neural networks as well as behaviors. Notably, practice relevant to mental or physical approach attracted great attention ...
Brain-immune interactions in health and disease
(2015)
Brain-immune interactions are essential to maintain health and their dysfunction contributes to diverse human diseases. Recent data show that haematopoietic processes and immune organs are under central autonomic control. ...
A Broader View for Plant EvoDevo: Novel Approaches for Diverse Model Systems
(2017)
This collection attempts to integrate work pertaining to a fundamental question in plant evolution: What are the molecular underpinnings for the origin of different plant forms? Among the many facets this question touches ...
Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches
(2017)
Mounting evidence shows that increasing numbers of children are being diagnosed with neurodevelopmental disorders, and it is clear that this increase cannot be explained by genetic background alone. A number of studies, ...