Publications
Now showing items 1141-1160 of 1372
Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy
(2018)
Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An ...
Sensory Hair Cell Death and Regeneration
(2016)
Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. ...
Signalling Pathways in Embryonic Development
(2017)
The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells ...
Significance of antigen and epitope specificity in tuberculosis
(2014)
Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of ...
Smelly Fumes: Volatile-Mediated Communication between Bacteria and Other Organisms
(2017)
This e-book summarizes recent advances in the young and rapidly developing field of microbial volatiles. Articles included here reveal novel information about the chemical diversity of bacterial and fungal volatiles, their ...
Social Hormones and Human Behavior: What Do We Know and Where Do We Go from Here
(2015)
Oxytocin (OT) and arginine vasopressin (AVP) are the paramount social hormones in mammals and accumulating evidence also strengthens the unique role of these neuropeptides also in human social behavior. Indeed from voles ...
Preclinical and clinical issues in Alzheimer's disease drug research and development
(2015)
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the ...
Precision Public Health
(2018)
Precision Public Health is a new and rapidly evolving field, that examines the application of new technologies to public health policy and practice. It draws on a broad range of disciplines including genomics, spatial data, ...
The state of the art in student engagement
(2015)
There is an extensive literature conducted from a range of theoretical perspectives and methodologies on the role of groups and student learning in higher education. However here the concept of the ‘group’ is heavily ...
Stem cells and progenitor cells in ischemic stroke - fashion or future?
(2016)
Stroke remains one of the most devastating diseases in industrialized countries. Recanalization of the occluded arterial vessel using thrombolysis is the only causal therapy available. However, thrombolysis is limited due ...
Serotonin and Memory
(2016)
The study of 5-hydroxytryptamine (5-HT) systems has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Increasing evidence suggests that 5-HT pathways, reuptake ...
Roles and mechanisms of parasitism in aquatic microbial communities
(2015)
Next Generation Sequencing technologies are increasingly revealing that microbial taxa likely to be parasites or symbionts are probably much more prevalent and diverse than previously thought. Every well studied free-living ...
The Roles of GnIH in Reproductive Function and Behavior
(2018)
Since the discovery of gonadotropin-releasing hormone (GnRH) at the beginning of 1970s, it has been believed that GnRH is the only hypothalamic neuropeptide that regulates gonadotropin release in vertebrates. In 2000, ...
The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders
(2015)
Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be ...
Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond
(2018)
Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading ...
Salinity Tolerance in Plants: Mechanisms and Regulation of Ion Transport
(2018)
Life presumably arose in the primeval oceans with similar or even greater salinity than the present ocean, so the ancient cells were designed to withstand salinity. However, the immediate ancestors of land plants most ...
Salicylic Acid Signaling Networks
(2016)
The small phenolic compound salicylic acid (SA) is critical for plant defense against a broad spectrum of pathogens. SA is also involved in multi-layered defense responses, from pathogen-associated molecular pattern triggered ...
Single Membrane Channels Formed by Connexins or Pannexins: Focus on the Nervous System
(2016)
Given that the extremely elaborated and dynamic functions performed by the nervous system require the close synchronization of brain cells, complex organisms have developed different mechanisms of intercellular communication. ...
Social Cognition, Motivation, and Interaction How Do People Respond to Threats in Social Interactions?
(2018)
f we want to understand people’s responses to threats in social interactions we can distinguish between three levels of analysis:On a social level of analysis we can describe people’s interpersonal behavior, on a cognitive ...
Stem Cell Genetic Fidelity
(2015)
The vision of this Frontiers in Oncology Research Topic on "Stem Cell Genetic Fidelity" had the goal of steeping a diverse range of research perspectives to a first comprehensive synthesis of thought on the questions of ...