Publications
Now showing items 1241-1260 of 1372
Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics
(2017)
Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are ...
Twenty Years After the Iowa Gambling Task: Rationality, Emotion, and Decision-Making
(2018)
The world is full of uncertainty. In unpredictable circumstances, can emotions facilitate advantageous decision-making? A neuroscience team, led by Antonio Damasio, explored this question using the Iowa Gambling Task (IGT). ...
Type I Chaperonins: Mechanism and Beyond
(2018)
Type I chaperonins are key players in maintaining the proteome of bacteria and organelles of bacterial origin. They are well known for their crucial role in mediating protein folding. For almost three decades, the molecular ...
Type I Interferon in Human Autoimmunity
(2015)
The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease. Type I interferons function ...
The Uncanny Valley Hypothesis and Beyond
(2018)
A field of theory and research is evolving around the question highlighted in the Uncanny Valley Hypothesis: How does high realism in anthropomorphic design influence human experience and behaviour? The Uncanny Valley ...
Understanding Developmental Dyslexia: Linking Perceptual and Cognitive Deficits to Reading Processes
(2016)
Understanding the mechanisms responsible for developmental dyslexia (DD) is a key challenge for researchers. A large literature, mostly concerned with learning to read in opaque orthographies, emphasizes phono-logical ...
Understanding Crohn's Disease: Immunity, Genes and Microbes
(2017)
Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and ...
Understanding the Role of Time-Dimension in the Brain Information Processing
(2017)
Optimized interaction of the brain with environment requires the four-dimensional representation of space-time in the neuronal circuits. Information processing is an important part of this interaction, which is critically ...
Understanding the Successful Coordination of Team Behavior
(2017)
In many areas of human life, people perform in teams. These teams’ performances depend, at least partly, on team members’ abilities to coordinate their contributions effectively. This includes the making of decisions and ...
T Cell Regulation by the Environment
(2015)
Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, ...
Today’s Nutrition and Tomorrow’s Public Health: Challenges and Opportunities
(2016)
At the dawn of the third millennium, we are confronted with a disturbing phenomenon: although global life expectancy still increases, this is not the case for healthy life expectancy! The explanation of this seemingly ...
Toll-Like Receptor Activation in Immunity vs. Tolerance
(2015)
The innate immune system has evolved means to recognize and react suitably to foreign entities such as infectious agents. In many cases infectious microorganisms threaten the integrity and function of the target organs or ...
Touch Screen Tablets Touching Children's Lives
(2018)
Touch screen tablets have greatly expanded the technology accessible to preschoolers, toddlers and even infants, given that they do not require the fine motor skills required for using traditional computers. Many parents ...
Toward a Unified View of the Speed-Accuracy Trade-Off: Behaviour, Neurophysiology and Modelling
(2016)
Everyone is familiar with the speed-accuracy trade-off (SAT). To make good choices, we need to balance the conflicting demands of fast and accurate decision making. After all, hasty decisions often lead to poor choices, ...
Towards a New Cognitive Neuroscience: Modeling Natural Brain Dynamics
(2014)
Decades of brain imaging experiments have revealed important insights into the architecture of the human brain and the detailed anatomic basis for the neural dynamics supporting human cognition. However, technical restrictions ...
Towards a molecular classification of colorectal cancer
(2015)
In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this ...
Towards an Integrated Approach to Measurement, Analysis and Modeling of Cortical Networks
(2016)
The amount of data being produced by neuroscientists is increasing rapidly, driven by advances in neuroimaging and recording techniques spanning multiple scales of resolution. The availability of such data poses significant ...
Towards an embodied science of intersubjectivity: Widening the scope of social understanding research
(2015)
An important amount of research effort in psychology and neuroscience over the past decades has focused on the problem of social cognition. This problem is understood as how we figure out other minds, relying only on ...
Towards embodied artificial cognition: TIME is on my side
(2015)
From the moment of birth, humans and animals are immersed in time: all experiences and actions evolve in time and are dynamically structured. The perception of time is thus a capacity indispensable for the control of ...
Towards Elimination of Dog Mediated Human Rabies
(2017)
Rabies is an ancient zoonotic viral disease that still exerts a high impact on human and animal health. The disease is almost 100% fatal after clinical signs appear, and it kills tens of thousands of people per year ...