Publications
Now showing items 1261-1280 of 1372
Towards translating research to clinical practice: Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury
(2015)
Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in ...
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs
(2017)
Tens of thousands of chemicals are released into the environment every day. High-throughput screening (HTS) has offered a more efficient and cost-effective alternative to traditional toxicity tests that can profile these ...
Toxicity of Pesticides on Health and Environment
(2018)
Public policy is regularly shaken by health crises or unexpected discoveries; future directions in toxicology assessment are therefore urgently needed. Convergent evidences suggest endocrine or nervous disrupting effects ...
Transcriptional Regulation in Cancers and Metabolic Diseases
(2015)
The transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression ...
Transcellular Cycles Underlying Neurotransmission
(2015)
Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important ...
The Transcriptional Regulation of Memory
(2016)
The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, ...
Transfer Cells
(2015)
Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth ...
Transitions Between Consciousness and Unconsciousness
(2018)
Over the last years, a large body of experimental data have been generated in the attempt to understand consciousness and its neural underpinnings. In this respect, particular interest has been paid to the attempt to ...
Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations
(2017)
Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s ...
Trauma; Psychosis and Posttraumatic Stress Disorder
(2017)
There is abundant evidence showing a strong association between trauma exposure, psychotic symptoms, and posttraumatic stress disorder (PTSD). Early trauma exposure contributes to the formation of psychotic symptoms and ...
Traumatic Brain Injury as a Systems Neuroscience Problem
(2017)
Traumatic brain injury (TBI) is traditionally viewed as an anatomic and neuropathological condition. Caring for TBI patients is a matter of defining the extent of an anatomical lesion, managing this lesion, and minimizing ...
The Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine
(2015)
Lung cancer is the leading cause of cancer related mortality in Canada and USA. Majority of the patients present in advanced stage of the disease and of these only about 2% will be alive at 5 years. NSCLC is the most common ...
Trends in Neuroergonomics: A Comprehensive Overview
(2017)
This Research Topic is dedicated to Raja Parasuraman who unexpectedly passed on March 22nd 2015. Raja Parasuraman’s pioneering work led the emergence of Neuroergonomics as a new scientific field. He combined his research ...
Trends in Comparative Endocrinology and Neurobiology
(2018)
The comparative approach takes advantage of the biological diversity to select the most appropriate model organism to tackle a scientific question. Comparisons between the endocrine and nervous systems accross species have ...
Trends in Regulatory Peptides
(2018)
Regulatory peptides represent the most diverse and versatile family of messenger molecules. They are produced by all living organisms from bacteria to mammals. They are involved in a wide variety of biological functions. ...
Trends in Neuroendocrinology
(2016)
Neuroendocrinology is the discipline that investigates the interplay between the nervous and endocrine systems i.e. the control of endocrine glands by the central and peripheral nervous systems, the action of hormones on ...
Testis cancer: Genes, environment, hormones
(2015)
Testicular cancer (TC) is the most common cancer in males aged 20-40 years, with a worldwide incidence of 7.5 per 100,000, but the rates vary considerably between countries and ethnic groups and there is evidence also for ...
Wiring Principles of Cerebral Cortex
(2015)
Cerebral cortex is probably the most complex biological network. Here many millions of individual neurons, the functional units of cortex, are interconnected through a massive yet highly organized pattern of axonal and ...
Women's Under-Representation in the Engineering and Computing Professions: Fresh Perspectives on a Complex Problem
(2018)
Understanding the many complexities that define gender inequality has been described by researchers as a grand challenge. Novel insights, innovation, a broader community to conduct research and to ascertain effective ...
Work-Life Balance: Essential or Ephemeral?
(2017)
Burn-out and suicide rates among physicians and scientists in academic medicine are at an all-time high and jeopardize the future of our entire profession. In the last 4 years alone, burn-out rates among physicians have ...