Publications
Now showing items 681-690 of 1372
Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases
(2015)
Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, ...
The molecular pathology of cognitive decline: Focus on metals
(2016)
In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing ...
Molecular Organization of Membranes: Where Biology Meets Biophysics
(2018)
Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed ...
Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications
(2015)
In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour ...
Molecular mechanisms for reprogramming hippocampal development and function by early-life stress
(2016)
The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive ...
Molecular Nanomachines of the Presynaptic Terminal
(2016)
Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in ...
Molecular Pathogenesis of Pneumococcus
(2017)
Streptococcus pneumoniae has been for decades the number one bacterial killer of children in the world. Although vaccination with pneumococcal vaccines [PCV7, PCV10, and PCV13 (children) or PPSV23 (adults)] has helped ...
NETosis 2: The Excitement Continues
(2017)
NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin ...
Neuro-motor control and feed-forward models of locomotion in humans
(2015)
Locomotion involves many different muscles and the need of controlling several degrees of freedom. Despite the Central Nervous System can finely control the contraction of individual muscles, emerging evidences indicate ...
Neuro-Immune Interactions in Inflammation and Autoimmunity
(2018)
The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal ...