Publications
Now showing items 561-640 of 1372
Is the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg?
(2018)
The high effectiveness of antibodies as anti-tumor therapeutic agents has led to a burst of research aiming to increase their therapeutic applications by the use of antibodies against new targets, new antibody formats or ...
The Ischemic Penumbra: Still the Target for Stroke Therapies?
(2015)
The ischemic penumbra was initially defined by Symon, Lassen and colleagues in the 1970s as an area of brain tissue with inadequate blood flow to maintain electric activity of neurons but adequate blood flow to preserve ...
The Foundation of Precision Medicine: Integration of Electronic Health Records with Nenomics Through Basic, Clinical, and Translational Research
(2016)
This eBook contains the 19 articles that were part of a Special Topic in Frontiers in Genetics entitled “Genetics Research in Electronic Health Records Linked to DNA Biobanks”. The Special Issue was published on-line in ...
Foundations of Theoretical Approaches in Systems Biology
(2019)
If biology in the 20th century was characterized by an explosion of new technologies and experimental methods, that of the 21st has seen an equally exuberant proliferation of mathematical and computational methods that ...
Image-Guided Radiotherapy for Effective Radiotherapy Delivery
(2016)
Image-guided radiotherapy (IGRT) is a new radiotherapy technology that combines the rapid dose fall off associated with intensity-modulated radiotherapy (IMRT) and daily tumor imaging allowing for high precision tumor dose ...
Imaging and monitoring astrocytes in health and disease
(2014)
Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory ...
Imaging in Acute Stroke - New Options and State of the Art
(2018)
One in six suffers a stroke during their lifetime and stroke remains the major cause of new onset disability in adulthood. The worldwide burden of stroke is increasing due to an ageing population, however, globally haft ...
Foot-and-Mouth Disease in Swine
(2017)
Foot-and-mouth disease (FMD) is one of the most devastating diseases of livestock. The research topic here features nine studies supplementing the state-of-the art of the knowledge on the pathogenesis and epidemiology of ...
Inorganic Biomaterials
(2016)
The intention of the editors A. R. Boccaccini and W. Höland has been to target this e-book to a broad readership and at the same time to present scientific contributions sufficiently detailed which discuss various specific ...
Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists
(2014)
Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. ...
Integrating Computational and Neural Findings in Visual Object Perception
(2016)
The articles in this Research Topic provide a state-of-the-art overview of the current progress in integrating computational and empirical research on visual object recognition. Developments in this exciting multidisciplinary ...
Integrative Research on Organic Matter Cycling Across Aquatic Gradients
(2017)
The goal of this research topic was to motivate innovative research that blurs traditional disciplinary and geographical boundaries. As the scientific community continues to gain momentum and knowledge about how the natural ...
Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment
(2017)
Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such ...
Inter-cellular Electrical Signals in Plant Adaptation and Communication
(2018)
Plants use the Sun's energy to synthesize the basic biomolecules that make up all the organic matter of all organisms of terrestrial ecosystems, including ourselves. Therefore, understanding their adaptive mechanisms to ...
Inter-healthcare Professions Collaboration: Educational and Practical Aspects and New Developments
(2016)
Settings, such as patient-centered medical homes, can serve as ideal places to promote interprofessional collaboration among healthcare providers (Fjortoft et al., 2016). Furthermore, work together by teams of interprofessional ...
Interactions between emotions and social context: Basic, clinical and non-human evidence
(2014)
The emotions that we feel and also those that we perceive in others are crucial to the social functioning of both humans and non-human animals. Although the role of context has been extensively studied in basic sensory ...
Interactions between the mammalian main and accessory olfactory systems
(2014)
The functional cross-talk and structural interaction between the main and accessory olfactory bulb is a central problem in mammalian sensory neurobiology. The early supposition that volatile substances and pheromones, most ...
Interdisciplinary Approaches to Multilingualism
(2015)
This research topic stems from the "Interdisciplinary Approaches to Multilingualism" conference, which was hosted by the Language Research Centre at the University of Calgary. It was the first conference of its kind, which ...
International Conference on Carbon Dioxide Utilisation (ICCDU) 2016
(2018)
Carbon dioxide utilisation is a growing field of research that spans early stage laboratory chemistry through to commercial exploitation. In 2013 the CO2Chem Network (www.co2chem.com) made a successful bid to hold the 14th ...
Ion Transport in Chloroplast and Mitochondria Physiology in Green Organisms
(2017)
Chloroplasts and mitochondria both have a prokaryotic origin, carry essential genes on their own highly reduced genome and generate energy in the form of ATP for the plant cell. The ion composition and concentration in ...
Ion Channel Trafficking and Cardiac Arrhythmias
(2018)
A well-adjusted expression of cardiac ion channels at the sarcolemma is of crucial importance for normal action potential formation and thus cardiac function. The cellular processes that transport channel proteins from the ...
Identifying the Epileptic Network
(2014)
An important area of current research in epilepsy focuses on identifying the specific regions within the brain that are affected in individuals with recurring seizures. The epileptogenic process may result not only in ...
Food cravings
(2015)
Food craving refers to an intense desire or urge to consume a specific food. In Western or Westernized societies, these craved foods usually have high palatability and are energy dense, that is, they have high sugar and/or ...
Innovative Radiopharmaceuticals in Oncology and Neurology
(2017)
The aim of this Research Topic was to assemble a series of articles describing basic, preclinical and clinical research studies on radiopharmaceuticals and nuclear medicine. The articles were written by attendees of the ...
The Insect Central Complex - From Sensory Coding to Directing Movement
(2018)
The most fundamental function of the brain is the analysis and integration of sensory information in order to generate motor commands that result in directed, meaningful interactions with the environment. This process can ...
Insights into Microbe-Microbe Interactions in Human Microbial Ecosystems: Strategies to be Competitive
(2016)
All parts of our body having communication with the external environment such as the skin, vagina, the respiratory tract or the gastrointestinal tract are colonized by a specific microbial community. The colon is by far ...
Insight and Intuition - Two Sides of the Same Coin?
(2018)
Insight and intuition might be the most mysterious and fascinating fields of human thinking and problem solving. They are different from standard and analytical problem solving accounts and provide the basis for creative ...
Institutional determinants of social inequality
(2016)
Understanding the factors that create and maintain social inequalities is a core question in social psychology. Research has so far mainly focused on the role of individual stereotyping, prejudice and discrimination. ...
Interaction of Nanomaterials with the Immune System: Role in Nanosafety and Nanomedicinenanomedicine
(2018)
The immune system has the double role of maintaining tissue integrity and homeostasis and of protecting the organism from possible dangers, from invading pathogens to environmentally-borne dangerous chemicals. New chemicals ...
Interaction of BCI with the underlying neurological conditions in patients: pros and cons
(2015)
The primary purpose of Brain Computer Interface (BCI) systems is to help patients communicate with their environment or to aid in their recovery. A common denominator for all BCI patient groups is that they suffer from a ...
Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer
(2016)
The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian ...
Interaction of Trypanosoma cruzi with Host Cells
(2014)
Trypanosoma cruzi is a pathogenic protozoan of the Trypanosomatidade Family, which is the etiological agent of Chagas’ disease. Chagas’ disease stands out for being endemic among countries in Latin America, affecting about ...
International Partnerships for Strengthening Health Care Workforce Capacity: Models of Collaborative Education
(2018)
A critical problem in resource-scarce countries across the globe is the shortage of appropriately trained health care providers. According to the World Health Organization, the current global health workforce shortage of ...
International Plant Proteomics Organization (INPPO) World Congress 2014
(2017)
The field of proteomics has advanced considerably over the past two decades. The ability to delve deeper into an organism’s proteome, identify an array of post-translational modifications and profile differentially abundant ...
International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future
(2018)
This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from ...
Interoception, Contemplative Practice, and Health
(2017)
There is an emergent movement of scientists and scholars working on somatic awareness, interoception and embodiment. This work cuts across studies of neurophysiology, somatic anthropology, contemplative practice, and ...
Interplay between NO Signalling, ROS, and the Antioxidant System in Plants
(2017)
Over the last decades, nitric oxide (NO) has emerged as an essential player in redox signalling. Reactive oxygen species (ROS) also act as signals throughout all stages of plant life. Because they are potentially harmful ...
Intrinsic motivations and open-ended development in animals, humans, and robots
(2015)
The aim of this Research Topic for Frontiers in Psychology under the section of Cognitive Science and Frontiers in Neurorobotics is to present state-of-the-art research, whether theoretical, empirical, or computational ...
Intra- and inter-species interactions in microbial communities
(2015)
Recent developments in various “OMICs” fields have revolutionized our understanding of the vast diversity and ubiquity of microbes in the biosphere. However, most of the current paradigms of microbial cell biology, and our ...
Intracellular biomineralization in bacteria
(2014)
Bacteria can sequester metals and other ions intracellularly in various forms ranging from poorly ordered deposits to well- ordered mineral crystals. Magnetotactic bacteria provide one example of such intracellular deposits. ...
Intrinsic Clocks
(2018)
"Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components ...
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands
(2015)
T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their ...
Investigating the human brainstem with structural and functional MRI
(2014)
The brainstem is one of the least understood parts of the human brain despite its prime importance for the maintenance of basic vital functions. Owing to its role as a relay station between spinal cord, cerebellum and ...
Investigating Human Nature and Communication through Robots
(2017)
The development of information technology enabled us to exchange more items of information among us no matter how far we are apart from each other. It also changed our way of communication. Various types of robots recently ...
Investigating Grammar in Autism Spectrum Disorders
(2018)
Autism Spectrum Disorder (ASD hereafter) is a neurodevelopmental condition characterized by deficits in communicative and social skills. The vast majority of research on language in ASD has focused on pragmatic difficulties, ...
Invisible, but how? The depth of unconscious processing as inferred from different suppression techniques
(2015)
To what level are invisible stimuli processed by the brain in the absence of conscious awareness? It is widely accepted that simple visual properties of invisible stimuli are processed; however, the existence of higher-level ...
Involvements of TRP Channels and Oxidative Stress in Pain
(2018)
Undoubtedly, pain conditions the quality of life of millions of people worldwide suffering a wide range of diseases. Major research efforts are being made by the international scientific community to determine the mechanisms ...
Ionotropic Glutamate Receptors Trafficking in Health and Disease
(2017)
The knowledge about the properties and importance of ionotropic glutamate receptor trafficking is ever increasing. Importantly, the pace of the progress has been accelerated in recent years. Here, our contributors provide ...
Karolinska Institutet 200-Year Anniversary Symposium on Injuries to the Spinal Cord and Peripheral Nervous System - An Update on Recent Advances in Regenerative Neuroscience
(2017)
The present E-book consists of original articles and reviews published in our Research Topic on injuries to the spinal cord and peripheral nerves and presents a wide array of novel findings and in depth discussions on ...
The Janus-Face of Language: Where Are the Emotions in Words and the Words in Emotions?
(2018)
<p>Language has long been considered independent from emotions. In the last few years however research has accumulated empirical evidence against this theoretical belief of a purely cognitive-based foundation of language. ...
Leading people - managing organizations: Contemporary public health leadership
(2015)
In this Research Topic, we provide a comprehensive overview of current public health leadership research, focusing on understanding the impact of leadership on the delivery of public health services. By bringing together ...
Madness and Creativity: Yes, No or Maybe?
(2015)
The pervasive idea that madness and creativity are intricately linked is one that holds tremendous fascination for both scientists and the general public alike. Although this view was at first largely driven by anecdotal ...
Linguistic Influences on Mathematical Cognition
(2017)
For many years, an abstract, amodal semantic magnitude representation, largely independent of verbal linguistic representations, has been viewed as the core numerical or mathematical representation This assumption has been ...
Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants
(2016)
Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly ...
Magnetoencephalography: an emerging neuroimaging tool for studying normal and abnormal human brain development
(2015)
Research on the human brain development has seen an upturn in the past years mostly due to novel neuroimaging tools that became available to study the anatomy and function of the developing brain. Magnetic Resonance Imaging ...
Manipulative approaches to human brain dynamics
(2015)
In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and ...
Manipulation of the host cell by viral auxiliary proteins
(2015)
Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular ...
Manipulation of the cellular microbicidal response and endocytic dynamic by pathogens membrane factors
(2015)
Intracellular pathogens, such as bacteria and parasites, have evolved specialized mechanisms to survive and replicate in their host, leading to disorders and diseases. The principle of these mechanisms is to reprogram the ...
LuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria
(2016)
The most common quorum sensing (QS) system in Gram-negative bacteria occurs via N-acyl homoserine lactone (AHLs) signals. An archetypical system consists of a LuxI-family protein synthesizing the AHL signal which binds at ...
Making Science Fun - A Tribute to Our Colleague and Friend, Prof. Antonius G. Rolink (1953-2017)
(2019)
This Research Topic honors the memory of Prof. Antonius “Ton” G. Rolink (April 19, 1953–August 06, 2017), our colleague, mentor and friend in immunology. It is now over a year since Ton left us. This article collection, ...
Microorganisms for Functional Food
(2016)
Nowadays, most of Western consumers are aware that a targeted diet could be an important tool for fighting ageing and diseases such as hypertension, diabetes, and obesity. Microorganisms may be exploited for setting up ...
Melt Water Retention Processes in Snow and Firn on Ice Sheets and Glaciers: Observations and Modeling
(2018)
Melt takes place where the surface of glaciers or ice sheets interacts with the atmosphere. While the processes governing surface melt are fairly well understood, the pathways of the meltwater, from its origin to the moment ...
Macrocognition: The Science and Engineering of Sociotechnical Work Systems
(2018)
The increasing complexity of work systems and changes in the nature of workplace technology over the past century have resulted in an exponential shift in the nature of work activities, from physical labor to cognitive ...
Language, Cognition and Gender
(2016)
Gender inequality remains an issue of high relevance, and controversy, in society. Previous research shows that language contributes to gender inequality in various ways: Gender-related information is transmitted through ...
A living history of immunology
(2015)
In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" ...
Liver Myofibroblasts
(2016)
Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades ...
Lateralization and cognitive systems
(2015)
Left-right asymmetries of structure and function are a common organization principle in the brains of humans and non-human vertebrates alike. While there are inherently asymmetric systems such as the human language system ...
Less and Non-invasive Hemodynamic Monitoring Techniques
(2018)
In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery ...
Mechanisms of neuroinflammation and inflammatory neurodegeneration in acute brain injury
(2015)
Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory ...
Mechanisms underlying firing in healthy and sick human motoneurons
(2015)
Since the latter half of the twentieth century an enormous amount of knowledge about mammalian motoneuron pools has been collected. This progress was enabled mostly by the development of the precise techniques of intracellular ...
Mechanisms of Persistence, Survival, and Transmission of Bacterial Foodborne Pathogens in Production Animals
(2018)
Foodborne illness resulting from food production animals is a global health concern, and the Centers for Disease Control estimate that one in six Americans will become sick with a foodborne illness each year. Of course ...
Mechanisms of Neuronal Migration during Corticogenesis
(2016)
The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks ...
Mechanisms of Neural Circuit Formation
(2015)
The formation of the proper pattern of neuronal circuits during development is critical for the normal function of the vertebrate brain and for the survival of the organism. Circuit tracing studies spanning the past 100 ...
Mechanisms Underpinning the Link between Emotion, Physical Health and Longevity
(2017)
The 1990’s was designated as ‘the decade of the brain’ and now, common mental disorders are described as ‘brain disorders’. Yet intense research interest on the brain has largely side-lined the body as a passive observer, ...
Mechanisms of Innate Neuroprotection
(2016)
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been ...
Microglia in Health and Disease: A Unique Immune Cell Population
(2018)
Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make ...
Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
(2018)
Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to ...
Melatonin in Plants
(2017)
This topic focuses on distribution, synthesis, metabolism, and the in vivo roles of melatonin in plants, with 1 editorial, 3 reviews, 21 original research studies and 1 corrigendum.
Memory Systems of the Addicted Brain: The Underestimated Role of Drug-Induced Cognitive Biases in Addiction and Its Treatment
(2018)
Drug addiction may be viewed as a form of learning during which strong associations linking actions to drug-seeking are expressed as persistent stimulus–response habits, thereby maintaining a vulnerability to relapse. ...
Learning to see (better): Improving visual deficits with perceptual learning
(2015)
Perceptual learning can be defined as a long lasting improvement in a perceptual skill following a systematic training, due to changes in brain plasticity at the level of sensory or perceptual areas. Its efficacy has been ...