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Aging and Age-related Disorders: From Molecular Mechanisms to Therapies

dc.contributor.authorTitorenko, Vladimir*
dc.date.accessioned2021-02-11T07:56:46Z
dc.date.available2021-02-11T07:56:46Z
dc.date.issued2019*
dc.date.submitted2019-12-09 11:49:15*
dc.identifier42479*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/40469
dc.description.abstractAging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.*
dc.languageEnglish*
dc.subjectQH301-705.5*
dc.subjectQ1-390*
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciencesen_US
dc.subject.otheradvanced glycated end products*
dc.subject.othermicroRNAs*
dc.subject.othern/a*
dc.subject.otherdifferentiation*
dc.subject.othertranscription*
dc.subject.otherskin absorption*
dc.subject.othercellular quiescence*
dc.subject.otherlifespan*
dc.subject.otherlongevity genes*
dc.subject.otherprotein kinases*
dc.subject.otherself-renewal*
dc.subject.othercircadian*
dc.subject.otherblood–brain barrier*
dc.subject.otheraging-related disorders*
dc.subject.othersirtuin-1*
dc.subject.otherinflammation*
dc.subject.otherarterial aging*
dc.subject.otherreactive oxygen species*
dc.subject.otherelectron microscopy*
dc.subject.otherreconstructed human skin*
dc.subject.otherrejuvenation*
dc.subject.otherlow-dose fluvastatin and valsartan combination*
dc.subject.otherinflammaging*
dc.subject.otherhematopoietic stem cell aging*
dc.subject.othercell cycle*
dc.subject.othermitochondria*
dc.subject.otherribose*
dc.subject.otherthe nervous system*
dc.subject.othernanomedicine*
dc.subject.otherproteostasis*
dc.subject.otheradult stem cells*
dc.subject.otherimmunosenescence*
dc.subject.othercell signaling*
dc.subject.othermechanisms of quiescence maintenance*
dc.subject.othermetabolism*
dc.subject.otheraging*
dc.subject.othermelatonin*
dc.subject.otherdiabetes*
dc.subject.othermechanisms of quiescence entry and exit*
dc.subject.otherDrosophila melanogaster*
dc.subject.otherGSK3 (glycogen synthase kinase 3)*
dc.titleAging and Age-related Disorders: From Molecular Mechanisms to Therapies*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03921-356-6*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
oapen.relation.isbn9783039213559*
oapen.relation.isbn9783039213566*
oapen.pages322*
oapen.edition1st*


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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/