Biomimetic Radical Chemistry and Applications

Chatgilialoglu, Chryssostomos

doi:10.3390/books978-3-03928-393-4

dc.contributor.author	Chatgilialoglu, Chryssostomos	*
dc.date.accessioned	2021-02-11T09:11:55Z
dc.date.available	2021-02-11T09:11:55Z
dc.date.issued	2020	*
dc.date.submitted	2020-04-07 23:07:09	*
dc.identifier	44857	*
dc.identifier.uri	https://directory.doabooks.org/handle/20.500.12854/42284
dc.description.abstract	The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator.	*
dc.language	English	*
dc.subject	QH301-705.5	*
dc.subject	Q1-390	*
dc.subject.classification	thema EDItEUR::P Mathematics and Science::PS Biology, life sciences	en_US
dc.subject.other	gold nanoparticles	*
dc.subject.other	inhomogeneous reactions	*
dc.subject.other	chemical nuclease	*
dc.subject.other	liposomal somatostatin	*
dc.subject.other	replication fork stalling	*
dc.subject.other	lipid bilayer membranes	*
dc.subject.other	2c-3e S?S-bonded intermediates	*
dc.subject.other	cell micropolarity maps	*
dc.subject.other	protein labeling	*
dc.subject.other	time-resolved spectroscopy	*
dc.subject.other	1	*
dc.subject.other	pulse radiolysis	*
dc.subject.other	nucleosides	*
dc.subject.other	2-thiouracil	*
dc.subject.other	[1	*
dc.subject.other	lipidomics	*
dc.subject.other	radicals	*
dc.subject.other	reactive aldehydes	*
dc.subject.other	iron porphyrin	*
dc.subject.other	photolysis	*
dc.subject.other	oxidative damage	*
dc.subject.other	free fatty acids	*
dc.subject.other	charge transfer	*
dc.subject.other	fragmentation	*
dc.subject.other	biomimetic radical reaction	*
dc.subject.other	sulfones	*
dc.subject.other	bioinspired chemical catalysis	*
dc.subject.other	genomic and epigenomic instability	*
dc.subject.other	ATRPase	*
dc.subject.other	DNA methylation	*
dc.subject.other	oxononenal	*
dc.subject.other	trans lipid	*
dc.subject.other	copper	*
dc.subject.other	membrane fluidity maps	*
dc.subject.other	mitochondrial uncoupling protein	*
dc.subject.other	heme	*
dc.subject.other	thiyl radicals	*
dc.subject.other	oxidation	*
dc.subject.other	anomeric spironucleosides	*
dc.subject.other	protein stability	*
dc.subject.other	laser flash photolysis	*
dc.subject.other	type 2 diabetes	*
dc.subject.other	stationary radiolysis	*
dc.subject.other	confocal microscopy	*
dc.subject.other	iron(IV)-oxo	*
dc.subject.other	5]-radical translocation	*
dc.subject.other	diabetes	*
dc.subject.other	DNA hole transfer	*
dc.subject.other	free radical oxidation	*
dc.subject.other	radical reaction	*
dc.subject.other	kinetic studies	*
dc.subject.other	circular dichroism	*
dc.subject.other	catalase activity	*
dc.subject.other	thiobases	*
dc.subject.other	intercalation	*
dc.subject.other	electron transfer	*
dc.subject.other	iron-mediated ATRP	*
dc.subject.other	Fenton reaction	*
dc.subject.other	EPR spectroscopy	*
dc.subject.other	glycogen phosphorylase	*
dc.subject.other	azidoalkylation	*
dc.subject.other	free radicals	*
dc.subject.other	gamma radiolysis	*
dc.subject.other	quantum dynamics	*
dc.subject.other	hydrogen peroxide	*
dc.subject.other	carboazidation	*
dc.subject.other	?OH and ?N3 radicals	*
dc.subject.other	5?	*
dc.subject.other	oligonucleotides	*
dc.subject.other	Raman spectroscopy	*
dc.subject.other	azides	*
dc.subject.other	peroxidation	*
dc.subject.other	photo-ionization	*
dc.subject.other	guanine quadruplexes	*
dc.subject.other	8-cyclopurines	*
dc.subject.other	beta cells	*
dc.subject.other	cross-link	*
dc.subject.other	miRNAs	*
dc.subject.other	oxidative DNA damage	*
dc.subject.other	DNA damage	*
dc.subject.other	modified nucleosides	*
dc.subject.other	Julia–Kocienski olefination	*
dc.subject.other	DNA oxidation	*
dc.subject.other	therapeutic proteins	*
dc.subject.other	DNA replication stress	*
dc.subject.other	electron holes	*
dc.subject.other	singlet oxygen	*
dc.subject.other	radiosensitizers	*
dc.subject.other	cellular response	*
dc.subject.other	hydroxynonenal	*
dc.subject.other	isomerization	*
dc.subject.other	?-radiolysis	*
dc.subject.other	histone modifications	*
dc.subject.other	8-oxo-dG	*
dc.subject.other	6-dioxa-4-azaspiro[4.5]decane	*
dc.subject.other	retarded delivery	*
dc.subject.other	reaction mechanism	*
dc.subject.other	DNA	*
dc.subject.other	albumin	*
dc.subject.other	TD-DFT methods	*
dc.subject.other	nucleobase derivatives	*
dc.subject.other	bio-mimicking catalyst	*
dc.title	Biomimetic Radical Chemistry and Applications	*
dc.type	book
oapen.identifier.doi	10.3390/books978-3-03928-393-4	*
oapen.relation.isPublishedBy	46cabcaa-dd94-4bfe-87b4-55023c1b36d0	*
oapen.relation.isbn	9783039283934	*
oapen.relation.isbn	9783039283927	*
oapen.pages	300	*
oapen.edition	1st	*

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