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DNA Replication Stress

dc.contributor.authorBrosh Jr, Robert M.*
dc.date.accessioned2021-02-11T11:37:45Z
dc.date.available2021-02-11T11:37:45Z
dc.date.issued2019*
dc.date.submitted2019-12-09 16:10:12*
dc.identifier42693*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/45331
dc.description.abstractThis Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.*
dc.languageEnglish*
dc.subjectQH301-705.5*
dc.subjectQ1-390*
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciencesen_US
dc.subject.otherWerner Syndrome*
dc.subject.othern/a*
dc.subject.otherA549 cells*
dc.subject.otherepigenetic*
dc.subject.otherneurodegeneration*
dc.subject.otherGenome integrity*
dc.subject.otheradaptation*
dc.subject.othercellular senescence*
dc.subject.othergenome instability*
dc.subject.otherWerner Syndrome Protein*
dc.subject.otherlipofuscin*
dc.subject.othercell cycle checkpoints*
dc.subject.otherexonuclease 1*
dc.subject.othertemplate-switching*
dc.subject.otherenergy metabolism*
dc.subject.othermutation frequency*
dc.subject.otherDNA replication*
dc.subject.otherfork regression*
dc.subject.othermotor neuron disease*
dc.subject.otherMicrosatellites*
dc.subject.otherAlzheimer’s disease*
dc.subject.otherchromatin remodeler*
dc.subject.otherrepair of DNA damage*
dc.subject.otherAP site analogue*
dc.subject.othermutagens*
dc.subject.otherreplication timing*
dc.subject.otherThermococcus eurythermalis*
dc.subject.othernucleolar stress*
dc.subject.othergene expression*
dc.subject.othermutations spectra*
dc.subject.otherorigin firing*
dc.subject.otherFanconi Anemia*
dc.subject.othersuperfamily 2 ATPase*
dc.subject.otherDNA translocation*
dc.subject.otherDNA repair*
dc.subject.otherSSB signaling*
dc.subject.otherhomologous recombination*
dc.subject.othercommon fragile sites*
dc.subject.other8-chloro-adenosine*
dc.subject.otherreplication*
dc.subject.othergenome stability*
dc.subject.othermutagenicity*
dc.subject.otherfork reversal*
dc.subject.othermultiple sclerosis*
dc.subject.othernon-B DNA*
dc.subject.otherprotein stability*
dc.subject.otherheterogeneity*
dc.subject.otherubiquitin*
dc.subject.otherSenTraGorTM (GL13)*
dc.subject.otherreplication restart*
dc.subject.otherEdU*
dc.subject.other?-arrestin*
dc.subject.otherNER*
dc.subject.otheraging*
dc.subject.otherSSB end resection*
dc.subject.otheroxidative stress*
dc.subject.otherATR*
dc.subject.otherdormant origins*
dc.subject.otherR loops*
dc.subject.otherDNA damage response*
dc.subject.otherDifficult-to-Replicate Sequences*
dc.subject.otherDNA double-strand repair*
dc.subject.otherendonuclease IV*
dc.subject.otherALS*
dc.subject.otherdouble strand break repair*
dc.subject.otherpremature aging*
dc.subject.otherreplication stress*
dc.subject.otherEXO1*
dc.subject.otherPOL?*
dc.subject.othertranslesion synthesis*
dc.subject.otherstrand displacements*
dc.subject.otherG2-arrest*
dc.subject.otherDNA replication pattern*
dc.subject.otherSSB repair*
dc.subject.othergenome integrity*
dc.subject.otherG protein-coupled receptor kinase interacting protein 2 (GIT2)*
dc.subject.otherMMR*
dc.subject.otherreplicative stress*
dc.subject.othersenolytics*
dc.subject.otherspacer*
dc.subject.otherinteractome*
dc.subject.otherATR-Chk1 DDR pathway*
dc.subject.otherC9orf72*
dc.subject.otherreplication fork restart*
dc.subject.othertranslesion DNA synthesis*
dc.subject.otherDNA damage*
dc.subject.othermismatch repair*
dc.subject.otherDNA replication stress*
dc.subject.otherDNA helicase*
dc.subject.otherPolymerase kappa*
dc.subject.otherDNA fiber assay*
dc.subject.otherH1299 cells*
dc.subject.otherTLS*
dc.subject.otherAPE2*
dc.subject.otherageing*
dc.subject.othercell death*
dc.subject.otherchromosome*
dc.subject.otherTopBP1*
dc.subject.otherbarley*
dc.subject.otherclock proteins*
dc.subject.otherpost-translational modification*
dc.subject.other8-oxoG*
dc.subject.otherS phase*
dc.subject.otherataxia telangiectasia mutated (ATM)*
dc.subject.otherG protein-coupled receptor (GPCR)*
dc.subject.otherPolymerase eta*
dc.subject.othercancer*
dc.subject.otherG protein-coupled receptor kinase (GRK)*
dc.subject.otherhelicase*
dc.subject.othergenomic instability*
dc.subject.otherParkinson’s disease*
dc.subject.othernucleotide excision repair*
dc.subject.otherSupF*
dc.titleDNA Replication Stress*
dc.typebook
oapen.identifier.doi10.3390/books978-3-03921-390-0*
oapen.relation.isPublishedBy46cabcaa-dd94-4bfe-87b4-55023c1b36d0*
oapen.relation.isbn9783039213900*
oapen.relation.isbn9783039213894*
oapen.pages368*
oapen.edition1st*


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