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Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

dc.contributor.authorPaolo Bonaldo*
dc.contributor.authorLuciano Merlini*
dc.contributor.authorEmanuele Marzetti*
dc.date.accessioned2021-02-11T22:20:42Z
dc.date.available2021-02-11T22:20:42Z
dc.date.issued2015*
dc.date.submitted2016-04-07 11:22:02*
dc.identifier18814*
dc.identifier.issn16648714*
dc.identifier.urihttps://directory.doabooks.org/handle/20.500.12854/55788
dc.description.abstractLoss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.*
dc.languageEnglish*
dc.relation.ispartofseriesFrontiers Research Topics*
dc.subjectRC321-571*
dc.subjectQ1-390*
dc.subject.classificationthema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciencesen_US
dc.subject.otherAging sarcopenia*
dc.subject.othermuscular dystrophy*
dc.subject.otherMitochondrial dysfunction*
dc.subject.othertherapy*
dc.subject.otherskeletal muscle*
dc.subject.otherAutophagy*
dc.subject.otherAnimal Models*
dc.subject.otherApoptosis*
dc.subject.othersatellite cells*
dc.subject.othermuscle imaging*
dc.titlePathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach*
dc.typebook
oapen.identifier.doi10.3389/978-2-88919-684-5*
oapen.relation.isPublishedBybf5ce210-e72e-4860-ba9b-c305640ff3ae*
oapen.relation.isbn9782889196845*
oapen.pages248*


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