Chapter 12 Modelling Threshold-Dependent Gene Drives: a Case Study Using Engineered Underdominance
Abstract
In this chapter, we outline a range of
modelling approaches that have been used
to demonstrate the key characteristics of
this approach, including threshold introduction
frequencies, reversibility, spatial limitation
and robustness to mutation/resistance.
We then go on to discuss alternative configurations
based on the use of sex-specific
components and their effect on introduction
thresholds. We conclude with a discussion on the cycle of information between mathematical
models and experimental data along
with a range of areas for future modelling
that will be important in providing information
on the anticipated effects of these systems
when released into target populations.